Hubungan Skor CURB-65 dengan Lama Rawat Inap pada Pneumonia Komunitas Dewasa Dengan Terapi Levofloksasin di Rumah Sakit Daerah Gunung Jati Cirebon

Authors

  • Marvela Fayza Nafiatha Universitas Swadaya Gunung Jati
  • Adetya Rahma Dinni Universitas Swadaya Gunung Jati
  • Emallia Fitriani Universitas Swadaya Gunung Jati

DOI:

https://doi.org/10.55606/termometer.v4i4.7017

Keywords:

Community-acquired Pneumonia, CURB-65, Duration of Antibiotic Therapy, Length of Hospital Stay, Levofloxacin

Abstract

Adult community-acquired pneumonia (CAP) contributes substantially to hospital admissions, especially among elderly and comorbid patients. Indonesia's PDPI guideline reports CAP incidence rising from 6 to 34 per 1,000 population between ages 18-39 and >75 years, with inpatient mortality of 5-20%. Levofloxacin is widely used empirically for its broad spectrum and rapid clinical improvement, yet local data on hospital stay and therapy duration remain limited. To describe hospital stay and levofloxacin duration by sex, age, CURB-65 score, and comorbidities, and their correlation among adult CAP patients at Gunung Jati Regional Hospital, Cirebon, 2025. Retrospective descriptive study using medical records, total sampling, and Spearman's correlation test. Of 55 patients, most were male (58.2%; consistent with Fésüs et al., 57.7%) and aged 45–64 years (47.3%). Leading comorbidities were cardiovascular disease (20.0%) and diabetes mellitus (14.5%). CURB-65 scores were mostly low-moderate (41.8% and 40.0%). Hospital stay and intravenous therapy were both most commonly 3–5 days (56.4% and 98.2%). CURB-65 correlated significantly but weakly with length of stay (r=0.290; p=0.032). Patients were predominantly middle-aged to older males with mild-to-moderate severity, hospitalized 3-5 days, and higher CURB-65 scores were linked to longer stays.

Downloads

Download data is not yet available.

References

Agung, A., Putra, N., Prasetya, R., Eka, I. G., Suteja, J., & Marani, P. D. (2023). Evaluasi penggunaan antibiotik dengan metode ATC/DDD dan DU90% pada pasien pneumonia di RSD X tahun 2022 Kabupaten Badung. Jurnal Mandala Pharmacon Indonesia, 9(2), 408–418. https://doi.org/10.35311/jmpi.v9i2.398

Calis, A. G., Karaboga, B., Uzer, F., Kaplan, N., Karaca, M., & Barı, R. (2025). Correlation of pneumonia severity index and CURB-65 score with neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, and monocyte/lymphocyte ratio in predicting in-hospital mortality for community-acquired pneumonia: Observational study. Journal of Clinical Medicine, 14(3), Article 728. https://doi.org/10.3390/jcm14030728

Candel, F. J., Salavert, M., Basaras, M., Borges, M., Cant, R., Cercenado, E., et al. (2023). Ten issues for updating in community-acquired pneumonia: An expert review. Journal of Clinical Medicine, 12(21), Article 6864. https://doi.org/10.3390/jcm12216864

Cao, G., Zhu, Y., Xie, X. N., Chen, Y., Yu, J., Zhang, J., et al. (2020). Pharmacokinetics and pharmacodynamics of levofloxacin in bronchial mucosa and lung tissue of patients undergoing pulmonary operation. Experimental and Therapeutic Medicine, 607–616. https://doi.org/10.3892/etm.2020.8715

Carlos, P., Gomes, R., Coelho, J., Chaves, C., Tuna, C., & Louro, M. (2023). CURB-65 and long-term mortality of community-acquired pneumonia: A retrospective study on hospitalized patients. Cureus, 15(3), Article e36052. https://doi.org/10.7759/cureus.36052

Cavallazzi, R., & Ramirez, J. A. (2022). How and when to manage respiratory infections out of hospital. European Respiratory Review, 31(166), Article 220092. https://doi.org/10.1183/16000617.0092-2022

Fachri, M., Hatta, M., Zakia, D., Akaputra, R., Wahab, A., Azhar, A., et al. (2025). Comparison of length of treatment and comorbidities in older and adult hospitalized patients with bacterial community-acquired pneumonia. Eurasian Journal of Medicine, 57(3), 1–5. https://doi.org/10.5152/eurasianjmed.2025.25910

Farouq Yousef, K., KhalidM Noor, S., Osman Elamin, M., Badri, H. M., Alharbi, W., Muhammad Alzhrani, A., et al. (2024). Severity assessment of patients having community-acquired pneumonia by using CURB-65 scoring system. International Journal of Multidisciplinary Research, 18(3), 1907–1914.

Fésüs, A., Baluku, P., Sipos, É., Somodi, S., Berczi-Kun, E., Lekli, I., et al. (2024). The effect of the antibiotic stewardship program (ASP) on community-acquired pneumonia (CAP): A before-after study. Frontiers in Pharmacology. https://doi.org/10.3389/fphar.2024.1406960

Gach, M. W., Lazarus, G., Simadibrata, M., Sinto, R., Saharman, R., Limato, R., et al. (2024). Antimicrobial resistance among common bacterial pathogens in Indonesia: A systematic review. The Lancet Regional Health—Southeast Asia, 26, Article 100414. https://doi.org/10.1016/j.lansea.2024.100414

Gaire, M., Koirala, D., Gautam, A., Mishra, B., Sapkota, R., Niraula, S., et al. (2026). Comparison of CURB-65 and qSOFA scores in predicting outcomes in community-acquired pneumonia. Annals of Medicine and Surgery, 88(2), 1287–1296. https://doi.org/10.1097/MS9.0000000000004444

Gokhale, S., Taylor, D., Gill, J., Hu, Y., Zeps, N., Lequertier, V., et al. (2026). Hospital length of stay prediction tools for all hospital admissions and general medicine populations: Systematic review and meta-analysis.

Hernández Puentes, J. S., Bastidas-Goyes, A. R., Tuta Quintero, E. A., Díaz Quijano, D. M., López Núñez, L. M., Castro Córdoba, J. D., et al. (2025). Comorbidome and community-acquired pneumonia: Analysis by age, sex, and intensive care unit admission. Science Progress, 108(4), 1–21. https://doi.org/10.1177/00368504251384203

Jones, B. E., Ramirez, J. A., Oren, E., Soni, N. J., Sullivan, L. R., Restrepo, M. I., et al. (2026). Diagnosis and management of community-acquired pneumonia: An official American Thoracic Society clinical practice guideline. American Journal of Respiratory and Critical Care Medicine, 212(1). https://doi.org/10.1164/rccm.202507-1692ST

Kaal, A. G., op de Hoek, L., Hochheimer, D. T., Brouwers, C., Wiersinga, W. J., Snijders, D., et al. (2023). Outcomes of community-acquired pneumonia using the Pneumonia Severity Index versus the CURB-65 in routine practice of emergency departments. ERJ Open Research, 9(3). https://doi.org/10.1183/23120541.00051-2023

Kaya, M., Oduncuoğlu, M. K., Yıldırım, H., Coşkun, A., Halıcı, A., & Tunc, Y. (2025). The effectiveness of CURB-65 and PSI scores in predicting hospital length of stay in patients diagnosed with community-acquired pneumonia in the emergency department. Van Medical Journal, 32(2), 63–69. https://doi.org/10.5505/vmj.2025.03521

Kementerian Kesehatan Republik Indonesia. (2015). Program pengendalian resistensi antimikroba di rumah sakit.

Kementerian Kesehatan Republik Indonesia. (2023). Pedoman nasional pelayanan kedokteran tata laksana pneumonia pada dewasa (No. HK.01.07/MENKES/2147/2023).

Kementerian Kesehatan Republik Indonesia. (2025). Strategi nasional pengendalian resistansi antimikroba sektor kesehatan tahun 2025–2029.

Khairani, S., Ramadaniati, H. U., & Sarnianto, P. (2023). Evaluation of antibiotic use with quantitative methods in hospitalization pneumonia patients at West Nusa Tenggara Hospital. Jurnal Ilmiah Farmasi, 21(2), 300–307. https://doi.org/10.35814/jifi.v21i2.1449

Lüthi-Corridori, G., Boesing, M., Roth, A., Leuppi-Taegtmeyer, A. B., Schuetz, P., & Leuppi, J. D. (2023). Predictors of length of stay, rehospitalization and mortality in community-acquired pneumonia patients: A retrospective cohort study. Journal of Clinical Medicine, 12(17), Article 5601. https://doi.org/10.3390/jcm12175601

Lv, C., Pan, T., Shi, W., Peng, W., Gao, Y., & Muhith, A. (2023). Establishment of risk model for elderly CAP at different age stages: A single-center retrospective observational study. Scientific Reports, 1–11. https://doi.org/10.1038/s41598-023-39542-3

Marziano, Y., Itzhak, D., Halperin, Y., Gershman, V., Avraham, A. S., Nirkis, M., et al. (2025). Profound anemia in hospitalized community acquired pneumonia patients is associated with increased mortality and is prevalent in all patients' age-groups: A retrospective analysis of 15,121 patients. BMC Infectious Diseases, 25(1). https://doi.org/10.1186/s12879-025-11744-2

Miyashita, N., Nakamori, Y., Ogata, M., Fukuda, N., & Yamura, A. (2020). Assessment of the pneumonia severity score in community-acquired and nursing and healthcare-associated pneumonia due to COVID-19.

Mulyawantie, V., Ramadaniati, H. U., Sarnianto, P., & Hidayat, T. (2023). Evaluasi pelaksanaan pengendalian resistensi antimikroba dalam meningkatkan kualitas penggunaan antibiotik pada pasien rawat inap pneumonia anak. Jurnal Kesehatan, 4(2), 173–181. https://doi.org/10.36590/kepo.v4i2.825

Nune, L., Ningrat, S., Apriliany, F., & Indriani, N. (2024). Analisis tingkat keparahan interaksi obat pada pasien community-acquired pneumonia (CAP) di RSUD Provinsi NTB. 01(04), 211–219. https://doi.org/10.64094/q3vjv691

Perhimpunan Dokter Paru Indonesia. (2022). Pneumonia komunitas.

Podder, V., & Singh, S. N. (2025). Levofloxacin. In StatPearls. StatPearls Publishing. https://www.ncbi.nlm.nih.gov/books/NBK545180/

Rastiti, L., Kristina, S. A., Andayani, T. M., et al. (2023). Analisis biaya penyakit pneumonia pada pasien dewasa di rumah sakit. Majalah Farmaseutik, 19(4), 527–534. https://doi.org/10.22146/farmaseutik.v19i4.80728

Senok, A., Thomsen, J., Abdulrazzaq, N. M., Menezes, G. A., & Moubareck, C. A. (n.d.). Antimicrobial resistance in Streptococcus pneumoniae: A retrospective analysis of emerging trends in the United Arab Emirates.

Theilacker, C., Guardado Escobar, M. E., Sato, R., Carrió, E., Basu, S., Tran, T. M. P., et al. (2025). The risk of cardiovascular, cerebrovascular and thromboembolic events after community-acquired pneumonia among adults: A systematic literature review. European Respiratory Review, 34(175). https://doi.org/10.1183/16000617.0197-2024

World Health Organization. (2023a). Global health estimates: Leading causes of death. https://www.who.int/data/gho/data/themes/mortality-and-global-health-estimates/ghe-leading-causes-of-death

World Health Organization. (2023b). Pneumonia. https://www.who.int/health-topics/pneumonia

Zeng, H., Yang, C., Jiang, M., Luo, X., Zhu, X., Zheng, X., et al. (2026). Predicting length of hospital stay in community-acquired pneumonia using clinical and treatment factors: A retrospective study with restricted cubic spline and piecewise regression analysis. Frontiers in Public Health. https://doi.org/10.3389/fpubh.2026.1768432

Zhao, H., Tu, J., She, Q., Li, M., Wang, K., Zhao, W., et al. (2023). Prognostic significance of frailty in hospitalized elderly patients with community-acquired pneumonia: A retrospective cohort study. BMC Geriatrics, 1–8. https://doi.org/10.1186/s12877-023-04029-3

Downloads

Published

2026-10-01

How to Cite

Marvela Fayza Nafiatha, Adetya Rahma Dinni, & Emallia Fitriani. (2026). Hubungan Skor CURB-65 dengan Lama Rawat Inap pada Pneumonia Komunitas Dewasa Dengan Terapi Levofloksasin di Rumah Sakit Daerah Gunung Jati Cirebon. Termometer: Jurnal Ilmiah Ilmu Kesehatan Dan Kedokteran, 4(4), 230–247. https://doi.org/10.55606/termometer.v4i4.7017

Similar Articles

<< < 5 6 7 8 9 10 11 12 13 14 > >> 

You may also start an advanced similarity search for this article.