Gambaran Pengetahuan Ibu-Ibu PKK Tentang Jamu Temulawak Sebagai Anti Kanker Payudara

Restu Ayu Eka Pustika Dewi; Lusiana Cici Sabarani

doi:10.55606/termometer.v1i3.1932

Authors

Restu Ayu Eka Pustika Dewi Universitas IVET
Lusiana Cici Sabarani Universitas IVET

DOI:

https://doi.org/10.55606/termometer.v1i3.1932

Keywords:

Herb, Temulawak, breast cancer

Abstract

Cancer rates in Indonesia increase significantly every year. One of the cancers with a high death rate is breast cancer. Breast cancer itself generally attacks women and is one of the most common cancers that occur in Indonesia. Jamu is a herbal drink that is still popular with people in Indonesia. Temulawak contains xanthorrizol essential oil which is capable of treating various pathological conditions. Jamu temulawak can potentially inhibit Ymb-1, T47D, and MCF-7 breast cancer cells. The purpose of this study was to describe the level of knowledge of PKK mothers about Jamu Temulawak as anti-breast cancer. The research method used in this study was descriptive analysis with cross-sectional sampling techniques. It was found that there were 33 respondents consisting of PKK RT 05 RW 02 Lamper Krajan Village, Lamper Lor Village, South Semarang District. Data was obtained from filling out the questionnaire by respondents who then processed the data using SPSS. The results of the study showed that the level of knowledge about temulawak herbal medicine as anti-breast cancer was in the sufficient category, namely there were 22 people (66.7%). The respondents' knowledge level about the processing of temulawak herbal medicine is still relatively low, namely 17 people (51.5%). The majority of respondents obtained information from electronic media, there were 31 people (93.9%). The importance of increasing the knowledge of mothers about Jamu Temulawak as anti-breast cancer to prevent an increase in cases of death caused by breast cancer.

References

Achkar, I. W., Abdulrahman, N., Al-Sulaiti, H., Joseph, J. M., Uddin, S., & Mraiche, F. (2018). Cisplatin based therapy: The role of the mitogen activated protein kinase signaling pathway. Journal of Translational Medicine, 16(1), 1–12. https://doi.org/10.1186/s12967-018-1471-1

Ali, Z., Putri, M. D., Marlina, D., Sainita, N., & Asda, V. D. (2022). Bioinformatic Study of the Active Compound Curcuma Zanthorrhiza ( Temulawak ) in Preventing Cancer. 1(01), 24–31.

Basry, S., Ibrahim, K., & Maryati, I. (2022). Pengalaman Menggunakan Terapi Komplementer Pada Pasien Kanker Payudara. Jurnal Keperawatan Silampari, 6(1), 794–809.

Daryanti, E. P., Asriningtyas, D. Z., & Kautsari, F. W. (2022). GAMBARAN PENGETAHUAN MASYARAKAT TENTANG MACAM RIMPANG TEMU SEBAGAI JAMU DI INDONESIA Edhita. E-Proceeding 2nd SENRIABDI 2022, 2, 631–635. https://jurnal.usahidsolo.ac.id/

Esquivel-Velázquez, M., Ostoa-Saloma, P., Palacios-Arreola, M. I., Nava-Castro, K. E., Castro, J. I., & Morales-Montor, J. (2015). The role of cytokines in breast cancer development and progression. Journal of Interferon and Cytokine Research, 35(1), 1–16. https://doi.org/10.1089/jir.2014.0026

Fu, Z., Li, S., Han, S., Shi, C., & Zhang, Y. (2022). Antibody drug conjugate: the “biological missile” for targeted cancer therapy. Signal Transduction and Targeted Therapy, 7(1). https://doi.org/10.1038/s41392-022-00947-7

Guerra-Martín, M. D., Tejedor-Bueno, M. S., & Correa-Casado, M. (2021). Effectiveness of complementary therapies in cancer patients: A systematic review. International Journal of Environmental Research and Public Health, 18(3), 1–10. https://doi.org/10.3390/ijerph18031017

Jacob, J. N., & Toloue, M. (2013). Biological studies of turmeric oil, part 1: Selective in vitro anticancer activity of turmeric oil (TO) and TO-paclitaxel combination. Natural Product Communications, 8(6), 807–810. https://doi.org/10.1177/1934578x1300800632

Kemenkes RI. (2021). Profil Kesehatan Indonesia. Pusdatin.Kemenkes.go.id

Khan, T., Ali, M., Khan, A., Nisar, P., Jan, S. A., Afridi, S., & Shinwari, Z. K. (2020). Anticancer plants: A review of the active phytochemicals, applications in animal models, and regulatory aspects. Biomolecules, 10(1). https://doi.org/10.3390/biom10010047

Liu, L., Liu, Y. P., Wang, J., An, L. W., & Jiao, J. M. (2016). Use of a knowledge-attitude-behaviour education programme for Chinese adults undergoing maintenance haemodialysis: Randomized controlled trial. Journal of International Medical Research, 44(3), 557–568. https://doi.org/10.1177/0300060515604980

Lu, W., & Kang, Y. (2019). Epithelial-mesenchymal plasticity in cancer progression and metastasis. Physiology & Behavior, 49(80), 678–687. https://doi.org/10.1016/j.devcel.2019.04.010

Marfianti, E. (2021). Peningkatan Pengetahuan Kanker Payudara dan Ketrampilan Periksa Payudara Sendiri (SADARI) untuk Deteksi Dini Kanker Payudara di Semutan Jatimulyo Dlingo. Jurnal Abdimas Madani Dan Lestari (JAMALI), 3(1), 25–31. https://doi.org/10.20885/jamali.vol3.iss1.art4

Musfiroh, I., Geganaputra, A., Diantini, A., Susilawati, Y., & Muchtaridi, M. (2020). Antiproliferation Assay of Essential Oil of Curcuma Rhizoma (Curcuma xanthorrhiza Roxb.) Against P388 Leukemia Cell. Indonesian Journal of Pharmaceutical Science and Technology, 7(3), 100. https://doi.org/10.24198/ijpst.v7i3.27210

Mutasar, A., Irawan, A., & Kabuhung, E. I. (2018). Pengaruh Media Elektronik Berbasis Android Mobile Terhadap Peningkatan Pengetahuan Pasien Tuberkulosis (Tb): Literature Review Ahmad. Information Management and Business Review, 36(4), 25–37. https://ojs.amhinternational.com/index.php/imbr/article/view/2461/1696

Nguyen, M., & Osipo, C. (2022). Targeting Breast Cancer Stem Cells Using Naturally Occurring Phytoestrogens. International Journal of Molecular Sciences, 23(12). https://doi.org/10.3390/ijms23126813

Oon, S. F., Nallappan, M., Tee, T. T., Shohaimi, S., Kassim, N. K., Sa’ariwijaya, M. S. F., & Cheah, Y. H. (2015). Xanthorrhizol: A review of its pharmacological activities and anticancer properties. Cancer Cell International, 15(1), 1–15. https://doi.org/10.1186/s12935-015-0255-4

Park, jae hyung, Pyun, woo yang, & Park, hyun woo. (2020). Cancer Metabolism: Phenotype, Signaling and Therapeutic Targets. https://doi.org/10.3390/cells9102308

Raden Ajeng Nursamtari, & Ade Zuhrotun. (2022). Review Artikel : Potensi Jamu Gendong Kunci Suruh Sebagai Agen Antikanker Dan Ko-Kemoterapi. Medical Sains : Jurnal Ilmiah Kefarmasian, 7(2), 47–62. https://doi.org/10.37874/ms.v7i2.347

Rhomadona, S. W. (2014). GAMBARAN TINGKAT PENGETAHUAN IBU HAMIL TENTANG EFEK SAMPING MENGKONSUMSI JAMU-JAMUAN DI BPS ISTIQOMAH SURABAYA. Kebidanan.

Sudayasa, I. P., Rahman, M. F., Eso, A., Jamaluddin, J., Parawansah, P., Alifariki, L. O., Arimaswati, A., & Kholidha, A. N. (2020). Deteksi Dini Faktor Risiko Penyakit Tidak Menular Pada Masyarakat Desa Andepali Kecamatan Sampara Kabupaten Konawe. Journal of Community Engagement in Health, 3(1), 60–66. https://doi.org/10.30994/jceh.v3i1.37

Torre, L. A., Siegel, R. L., Ward, E. M., & Jemal, A. (2016). Global cancer incidence and mortality rates and trends - An update. Cancer Epidemiology Biomarkers and Prevention, 25(1), 16–27. https://doi.org/10.1158/1055-9965.EPI-15-0578

Vageli, D. P., Doukas, S. G., Spock, T., & Sasaki, C. T. (2018). Curcumin prevents the bile reflux-induced NF-κB-related mRNA oncogenic phenotype, in human hypopharyngeal cells. Journal of Cellular and Molecular Medicine, 22(9), 4209–4220. https://doi.org/10.1111/jcmm.13701

Wang, M., Jiang, S., Zhou, L., Yu, F., Ding, H., Li, P., Zhou, M., & Wang, K. (2019). Potential Mechanisms of Action of Curcumin for Cancer Prevention: Focus on Cellular Signaling Pathways and miRNAs. International Journal of Biological Sciences, 15(6), 1200–1214. https://doi.org/10.7150/ijbs.33710

Widiyastuti, Y., Marfuatush Sholikhah, I. Y., & Haryanti, S. (2019). Efek Sitotoksik Formula Jamu Daun Sirsak, Buah Takokak, dan Umbi Bidara Upas terhadap Sel Kanker Payudara MCF-7. Jurnal Kefarmasian Indonesia, 9(2), 140–149. https://doi.org/10.22435/jki.v9i2.1049

World Health Organization. (2022). Cancer. https://www.who.int/news-room/fact-sheets/detail/cancer

Xie, F., Zhou, X., Su, P., Li, H., Tu, Y., Du, J., Pan, C., Wei, X., Zheng, M., Jin, K., Miao, L., Wang, C., Meng, X., van Dam, H., ten Dijke, P., Zhang, L., & Zhou, F. (2022). Breast cancer cell-derived extracellular vesicles promote CD8+ T cell exhaustion via TGF-β type II receptor signaling. Nature Communications, 13(1). https://doi.org/10.1038/s41467-022-31250-2

Yeo, syn kok, & Guan, jun lin. (2017). Breast Cancer: Multiple Subtypes within a Tumor? Trends in Cancer, 176(3), 139–148. https://doi.org/10.1053/j.gastro.2016.08.014.CagY

Zafrial, R. M., & Amalia, R. (2018). Artikel Tinjauan : Anti Kanker dari Tanaman Herbal. Farmaka, 16(1), 15–23.