Identifikasi Drug Related Problems (DRPs) Pada Pasien Pediatri Penderita Epilepsi Rawat Jalan Di RSUD Embung Fatimah Kota Batam

Faizah Zalsabila; Aprilya Sri Rachmayanti; Ghalib Syukrillah Syahputra

doi:10.55606/detector.v3i4.5753

Authors

Faizah Zalsabila Institut Kesehatan Mitra Bunda
Aprilya Sri Rachmayanti Institut Kesehatan Mitra Bunda Batam
Ghalib Syukrillah Syahputra Institut Kesehatan Mitra Bunda Batam

DOI:

https://doi.org/10.55606/detector.v3i4.5753

Keywords:

American Society of Hospital Pharmacist (ASHP), Drug Related Problems (DRPs), Epilepsy, Pediatrics, Valproic Acid

Abstract

Epilepsy is one of the most common chronic neurological disorders in children. Long-term use of antiepileptic drugs carries the risk of Drug Related Problems (DRPs) such as drug interactions, inappropriate dosing, and untreated indications. This study aimed to identify the types and incidence of DRPs in pediatric epilepsy outpatients at Embung Fatimah General Hospital, Batam. This was a descriptive, non-experimental study with a retrospective design. Data were collected from pediatric medical records (<18 years) between January–December 2024, with a total of 45 patients. DRPs were identified using the American Society of Hospital Pharmacist (ASHP) classification. Of 45 patients, the majority were aged 1–5 years (38%) and female (53%). The most frequently used antiepileptic drug was sodium valproate (56.36%). Identification DRPs included drug interactions (63.16%), untreated indications (5.26%), and inappropriate drug selection (5.26%). No cases of overdose or failure to receive medication were found. The most dominant DRP in pediatric epilepsy patients was drug interactions, particularly between valproic acid and folic acid.

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References

Al-Azzam, S. I., Alzoubi, K. H., AbuRuz, S., & Alefan, Q. (2017). Drug-related problems in epilepsy patients: A systematic review. Seizure, 53, 88–95. https://doi.org/10.1016/j.seizure.2017.11.005

Anindya, I., Suryani, D., & Lestari, R. (2021). Epidemiologi epilepsi pada anak dan dewasa di Indonesia. Jurnal Neurologi Indonesia, 39(2), 85–92.

Bator, R. J., Bryan, A. D., & Schultz, P. W. (2011). Who Gives a Hoot?: Intercept Surveys of Litterers and Disposers. Environment and Behavior, 43(3), 295–315. https://doi.org/10.1177/0013916509356884.

Berg, A. T., & Shinnar, S. (1996). Complex febrile seizures. Epilepsia, 37(2), 126–133. https://doi.org/10.1111/j.1528-1157.1996.tb00006.x

Camfield, P., & Camfield, C. (2015). Incidence, prevalence and aetiology of seizures and epilepsy in children. Epileptic Disorders, 17(2), 117–123.

Cipolle, R. J., Strand, L. M., & Morley, P. C. (2012). Pharmaceutical care practice: The patient-centered approach to medication management (3rd ed.). McGraw-Hill.

Fisher, R. S., Acevedo, C., Arzimanoglou, A., et al. (2014). ILAE official report: A practical clinical definition of epilepsy. Epilepsia, 55(4), 475–482. https://doi.org/10.1111/epi.12550

Hasibuan, R., & Dimyati, Y. (2020). Epilepsi dan kejang demam pada anak. Jurnal Kesehatan Anak Indonesia, 11(1), 15–22.

Hepler, C. D., & Strand, L. M. (1990). Opportunities and responsibilities in pharmaceutical care. American Journal of Hospital Pharmacy, 47(3), 533–543.

Hidayati, S.N. (2016). Pengaruh Pendekatan Keras dan Lunak Pemimpin Organisasi terhadap Kepuasan Kerja dan Potensi Mogok Kerja Karyawan. Jurnal Maksipreneur: Manajemen, Koperasi, dan Entrepreneurship, 5(2), 57-66. http://dx.doi.org/10.30588/SOSHUMDIK.v5i2.164.

Risdwiyanto, A. & Kurniyati, Y. (2015). Strategi Pemasaran Perguruan Tinggi Swasta di Kabupaten Sleman Yogyakarta Berbasis Rangsangan Pemasaran. Jurnal Maksipreneur: Manajemen, Koperasi, dan Entrepreneurship, 5(1), 1-23. http://dx.doi.org/10.30588/SOSHUMDIK.v5i1.142.

Shinnar, S., & Glauser, T. A. (2002). Febrile seizures. Journal of Child Neurology, 17(1_suppl), S44–S52.

Strand, L. M., Cipolle, R. J., Morley, P. C., & Frakes, M. J. (2018). Pharmaceutical care practice (4th ed.). McGraw-Hill.

Suria, A., Putri, R. A., & Hidayat, A. (2023). Identifikasi drug related problems pada pasien epilepsi rawat jalan. Jurnal Farmasi Klinik Indonesia, 12(3), 145–153.

World Health Organization. (2023). Epilepsy: A public health imperative. WHO Press.