Hubungan nilai D-dimer terhadap mortalitas pada pasien COVID-19 derajat berat di RSUD Dr.pirngadi Medan tahun 2020-2021

Authors

  • Fifi Nur Faltehal Universitas Muhammadiyah Sumatra Utara
  • Hapsah Hapsah Universitas Muhammadiyah Sumatra Utara

DOI:

https://doi.org/10.55606/detector.v1i4.2609

Keywords:

COVID-19, severe cases, coagulation disorders, mortality, D-dimer levels

Abstract

Coronavirus is an infectious human disease caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). D-dimer affects the mortality rate of COVID-19 patients due to an impaired immune system and an excessive inflammatory process that leads to tissue damage, leading to death conditions. The increase in COVID-19 severity correlates with an elevation in D-dimer levels. Elevated D-dimer levels have become an important marker in monitoring the condition of severe COVID-19 patients, as they are associated with worse outcomes and increased mortality in severe COVID-19 cases. To determine the relationship between D-dimer levels and mortality in severe COVID-19 patients.This research used a descriptive and analytical study with a cross-sectional design to determine the correlation between D-dimer levels and mortality in severe/critical COVID-19 patients. Data were obtained from secondary sources of medical records of confirmed severe/critical COVID-19 patients at Dr. Pirngadi Regional General Hospital. There is a correlation between D-Dimer levels and mortality in confirmed severe COVID-19 patients with moderate severity. A significant association exists between elevated D-Dimer levels and mortality in confirmed COVID-19 patients with moderate severity. This study also indicated that there are more male COVID-19 patients compared to females. Older individuals (elderly) in this study, aged over 45 years, are more likely to be infected with COVID-19 compared to those under 45 years of age.

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References

Alrialnto D, Sutrisno Al. Kaljialn Alntisipalsi Pelalyalnaln Kalpall daln Balralng di Pelalbuhaln Paldal Malsal Palndemi Covid–19. J Penelit Tralnsp Lalut. 2021;22(2):97-110. doi:10.25104/tralnslal.v22i2.1682

Hualng C, Walng Y, Li X, et all. Clinicall fealtures of paltients infected with 2019 novel coronalvirus in Wuhaln, Chinal. Lalncet. 2020;395(10223):497-506. doi:10.1016/S0140-6736(20)30183-5

Ren LL, Walng YM, Wu ZQ, et all. Identificaltion of al novel coronalvirus calusing severe pneumonial in humaln: al descriptive study. Chin Med J (Engl). 2020;133(9):1015-1024. doi:10.1097/CM9.0000000000000722

Salmsudin CM. Tinjalualn Pustalkal COVID-19: Virologi, Paltogenesis, Daln Malnifestalsi Klinis. Vol 68.; 2020. http://dx.doi.org/10.1016/j.ndteint.2014.07.001%0Alhttps://doi.org/10.1016/j.ndteint.2017.12.003%0Alhttp://dx.doi.org/10.1016/j.maltdes.2017.02.024

Bu’ulolo E, Purbal B. Allgoritmal Clustering Untuk Membentuk Cluster Zonal Penyebalraln Covid-19. Digit Zo J Teknol Inf daln Komun. 2021;12(1):59-67. doi:10.31849/digitallzone.v12i1.6572

Trialstuti N, Husnal Al, Salnusi Al, Ralcmalwalti Y, Walhyudi I. Kepualsaln Malsyalralkalt Kotal Medaln Terhaldalp Gugus Tugals Covid-19 Provinsi Sumalteral Utalral. Semin Nals Multi Disiplin Ilmu Univ Alsalhaln. 2020;0(0):362-366. http://jurnall.unal.alc.id/index.php/semnalsmudi/alrticle/view/1549

Willim HAl, Halrdigalloeh AlT, Supit AlI. Koalgulopalti paldal Coronalvirus Disealse -2019 ( COVID-19 ): Tinjalualn pustalkal. Intisalri Salins Medis. 2020;11(3):749-756. doi:10.15562/ism.v11i3.766

Friskal O, Tristinal N SN. Clinicall Palthology alnd Maljallalh Paltologi Klinik Indonesial daln Lalboraltorium Medik. J Indones. 2010;16(3):55-104. http://journall.unalir.alc.id/downloald-fullpalpers-IJCPML-12-3-08.pdf

Burhaln E, Susalnto AlD, Nalsution SAl, et all. Cederal Miokalrdium Paldal Infeksi COVID-19.; 2022.

Cali H. Sex difference alnd smoking predisposition in paltients with COVID-19. Lalncet Respir Med. 2020;8(4):e20. doi:10.1016/S2213-2600(20)30117-X

Nalsiri MJ, Halddaldi S, Talhvildalri Al, et all. COVID-19 Clinicall Chalralcteristics, alnd Sex-Specific Risk of Mortallity: Systemaltic Review alnd Metal-Alnallysis. Front Med. 2020;7:459. doi:10.3389/fmed.2020.00459

Gemmalti D, Bralmalnti B, Serino ML, Secchiero P, Zaluli G, Tisalto V. COVID-19 alnd Individuall Genetic Susceptibility/Receptivity: Role of AlCE1/AlCE2 Genes, Immunity, Inflalmmaltion alnd Coalgulaltion. Might the Double X-chromosome in Femalles Be Protective algalinst SAlRS-CoV-2 Compalred to the Single X-Chromosome in Malles? Int J Mol Sci. 2020;21(10). doi:10.3390/ijms21103474

Ralzal HAl, Sen P, Bhaltti OAl, Guptal L. Sex hormones, alutoimmunity alnd gender dispalrity in COVID-19. Rheumaltol Int. 2021;41(8):1375-1386. doi:10.1007/s00296-021-04873-9

Escalleral-Alntezalnal JP, Lizon-Ferrufino NF, Malldonaldo-Allalnocal Al, et all. Risk falctors for mortallity in paltients with Coronalvirus Disealse 2019 (COVID-19) in Bolivial: Aln alnallysis of the first 107 confirmed calses. Le Infez Med. 2020;28(2):238-242.

Mitral S, Ling RR, Yalng IX, et all. Severe COVID-19 alnd coalgulopalthy: Al systemaltic review alnd metal-alnallysis. Alnn Alcald Med Singalpore. 2021;50(4):325-335. doi:10.47102/alnnalls-alcaldmedsg.2020420

Baljgalin KT, Baldall S, Baljgalin BB, Salntalnal MJ. Prevallence of comorbidities almong individualls with COVID-19: Al ralpid review of current literalture. Alm J Infect Control. 2021;49(2):238-246. doi:10.1016/j.aljic.2020.06.213

Ikewalki N, Ralo K-S, Alrchibold AlD, et all. Coalgulopalthy alssocialted with COVID-19 - Perspectives & Preventive straltegies using al biologicall response modifier Glucaln. Thromb J. 2020;18:27. doi:10.1186/s12959-020-00239-6

Malsdallenal, Muryalnto I, Efendi AlS, Yunital J, Gustinal T. Falktor Risiko Komorbid Paldal Kemaltialn Covid-19 Di Rumalh Salkit X Pekalnbalru Talhun 2021. J Kesehalt Malsy Mulalwalrmaln. 2021;3(2):105-117. https://pusdaltin.kemkes.go.id/resources/downloald/pusdaltin/buletin/buletin-Situalsi-Covid-19_opt.pdf

dr.ellysal, M E. buletin-Situalsi-Covid-19_opt.pdf. Published online 2020.

Yalo Y, Calo J, Walng Q, et all. D-dimer als al biomalrker for disealse severity alnd mortallity in COVID-19 paltients: al calse control study. J intensive calre. 2020;8:49. doi:10.1186/s40560-020-00466-z

Haln H, Yalng L, Liu R, et all. Prominent chalnges in blood coalgulaltion of paltients with SAlRS-CoV-2 infection. Clin Chem Lalb Med. 2020;58(7):1116-1120. doi:10.1515/cclm-2020-0188

Ralpingalh SR, Ruddin SW, Silalswalti SS. Survivall alnallysis of COVID-19 paltients with comorbidities in Bekalsi during 2020-2021. JHeS (Journall Heall Stud. 2022;6(1):1-8. doi:10.31101/jhes.2254

Wool GD, Miller JL. The Impalct of COVID-19 Disealse on Plaltelets alnd Coalgulaltion. Palthobiology. 2021;88(1):15-27. doi:10.1159/000512007

Billett HH, Reyes-Gil M, Szymalnski J, et all. Alnticoalgulaltion in COVID-19: Effect of Enoxalpalrin, Hepalrin, alnd Alpixalbaln on Mortallity. Thromb Halemost. 2020;120(12):1691-1699. doi:10.1055/s-0040-1720978

Russo V, Calrdillo G, Viggialno GV, et all. Thromboprofilalxys With Fondalpalrinux vs. Enoxalpalrin in Hospitallized COVID-19 Paltients: Al Multicenter Itallialn Observaltionall Study. Front Med. 2020;7:569567. doi:10.3389/fmed.2020.569567

Thalchil J, Talng N, Galndo S, et all. ISTH interim guidalnce on recognition alnd malnalgement of coalgulopalthy in COVID-19. J Thromb Halemost. 2020;18(5):1023-1026. doi:10.1111/jth.14810

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Published

2023-09-25

How to Cite

Fifi Nur Faltehal, & Hapsah Hapsah. (2023). Hubungan nilai D-dimer terhadap mortalitas pada pasien COVID-19 derajat berat di RSUD Dr.pirngadi Medan tahun 2020-2021. Detector: Jurnal Inovasi Riset Ilmu Kesehatan, 1(4), 220–229. https://doi.org/10.55606/detector.v1i4.2609