Uji Aktivitas Antiinflamasi Estrak Sirih Cina (Peperomia Pellusida) Pada Tikus Jantan Galur Wistar Yang Diinduksi Karagenan
DOI:
https://doi.org/10.55606/detector.v1i3.2428Keywords:
Anti-Inflammatory, Animal Test, Carrageenan, Chinese Betel PlantAbstract
Chinese betel plant (Peperomia pellucida), an herbal plant belonging to the Piperaceae family, Chinese betel plant (Peperomia pellucida). Research Stages: sample collection, extract preparation, extract standardization, determination of non-specific parameters, phytochemical screening, preparation of test solutions, anti-inflammatory activity tests, treatment of test animals. The results of maceration were filtered using filter paper, then the entire filtrate was concentrated using a vacuum evaporator and water bath at 60℃ to obtain a thick extract. The yield of 96% ethanol extract from Chinese betel powder (Peperomia pellucida) obtained was 4.531%. Based on the results, it has non-specific characteristics, namely drying shrinkage of 9.26%, ash content of 7.9% and water content of 4.15%. Phytochemical screening the compound tested was positive, A dose of 150 mg/kgBB is also an effective dose in inhibiting the formation of edema seen from the effect it gives is stable and has the highest percentage of edema inhibition compared to other doses, which is 34,35%.
References
Andini, Dewi Kunti Malangsari. (2019). Penyuluhan Pembuatan Bunga Telang Kering Sebagai Seduhan Teh Kepada Anak Panti Asuhan Yatim Putra Baiti Jannati. Jurnal Abdimas Unwahas. 2(4)
Ayu, R., & Wardhani, P. (2015). Uji Aktivitas Antibakteri Ekstrak Kulit Buah Rambutan (Nephelium lappaceum L.,) Pada Bakteri. IJCS - Indonesia Journal of Chemical Science, 4(1), 1–6.
Departemen Kesehatan Republik Indonesia. (2000). Parameter Standar Umum Ekstrak Tumbuhan Obat. Jakarta: Direktorat Jenderal Pengawas Obat dan Makanan. Hal 9-11.
Departemen Kesehatan Republik Indonesia. (2008). Farmakope Herbal Indonesia. Edisi Pertama. Jakarta: Departemen Kesehatan RI. Hal. 171
Dahlan, M. S. 2012. Statistik Untuk Kedokteran dan Kesehatan: Deskriptif, Bivariat, dan Multivariat, Dilengkapi Aplikasi dengan Menggunakan SPSS. Edisi 5. Jakarta: Salemba Medika.
Departemen Kesehatan RI. (2000). Parameter Standar Umum Ekstrak Tanaman Obat. In Departemen Kesehatan RI
Depkes RI. 1979. Farmakope Indonesia Edisi III. Jakarta: Departemen Kesehatan Republik Indonesia. Hal: 3-9.
Depkes RI. 2000. Parameter Standar Umum Ekstrak Tumbuhan Obat. Cetakan I. Jakarta: Departemen Kesehatan Republik Indonesia. Hal: 10-11.
Hassan, N. M., & Laily, A. N. (2014). Uji Kandungan Flavonoid dan Perbandingan Aktivitas Antioksidan Pada Ekstrak Etanol Simplisia Bunga Pepaya Gantung Saat Kuncup dan Mekar. Jurnal Skrining Bioaktif, 1(1), 1–15. https://doi.org/10.13140/RG.2.2.19762.40647
Hashimi, A., Siddiqui, A., Ahmed, Y., Siraj, M. B., & Khatoon, R. (2019). Quality control and phytochemical validation of Saussurea lappa (Costus/Qust). International Journal of Green Pharmacy, 14(1), 38–43
Ningsih, D. S., Henri, H., Roanisca, O., & Gus Mahardika, R. (2020). Skrining Fitokimia dan Penetapan Kandungan Total Fenolik Ekstrak Daun Tumbuhan Sapu-Sapu (Baeckea frutescens L.). Biotropika: Journal of Tropical Biology, 8(3), 178–185. https://doi.org/10.21776/ub.biotropika.2020.008.03.06
Utami, et al. (2011). Efek Antiinflamasi Ekstrak Daun Sembukan (Paederia scandens) Pada Tikus Wistar. Majalah Obat Tradisional, 16(2), 95 – 100.
Kristanti, Alfinda Novi. (2008). Buku Ajar Fitokimia. Surabaya: Universitas Airlangga Press.
Ramadhani, Nur, and Sri Adi Sumiwi. 2016. “Aktivitas Antiinflamasi Berbagai Tanaman Diduga Berasal Dari Flavonoid.” Farmaka 14(2):111–23.
Ravi V, Saleem TSM, Patel SS, Raamamurthy J, Gauthaman K. (2009). Anti_inflammatoryEffect of Methanolic Extract of Solanum nigrum Linn Berries. International Journal of Applied Research in Natural Products, 2(2).33-36.
Rubin, Emanuel and Howard M. Reisner. (2011). Essentials of Robin’s Pathology Sixth edition. Lippincott Williams & Wilkins : Printed in China.
WHO. (2000). General Guidelines for Methodologies on Research and Evaluation of Traditional Medicine World Health Organization.
