Perbedaan Indeks Massa Tubuh pada Ibu Hamil dengan Preeklamsi Ringan, Berat, dan Eklamsi di Rumah Sakit Umum Daerah (RSUD) Ciawi
DOI:
https://doi.org/10.55606/detector.v1i3.2182Keywords:
preeclampsia, eclampsia, body mass indexAbstract
Background: Preclampsia is a one of complication in pregnancy characterised by systolic blood pressure ≥140 mmHg and/or diastolic blood pressure ≥90 mmHg and proteinuria (≥300mg/24hours in urine; protein/creatinine ≥0.3; dipstick protein +1; and/or with additional symptoms. Eclampsia is a severe form of preeclampsia where the mother experiences seizures and/or coma. There are various risk factors for preeclampsia and eclampsia, one of which is the mother's body mass index (BMI). Excessive maternal weight before pregnancy, as well as excessive weight gain during pregnancy are at risk for preeclampsia.
Methods: This study used medical records from the Ciawi General Hospital in 2020, and cross-sectional observational study was carried out. Pregnant women with eclampsia and preeclampsia were the study's population. This study used total sampling as its sampling method, and body mass index measurements were made using information from medical records. The Kruskall Wallis alternative test was utilized in place of the One Way Anova as the hypothesis test in this investigation. In this investigation, a 5% level of significance is expected.
Results: This study involved 190 respondents who met the inclusion criteria. The statistical test results showed no significant difference in mean body mass index between the eclampsia, severe preeclampsia, and mild preeclampsia groups (P-value: 0.688). This difference is expected due to the small number of samples and/or the high variability of the samples.
Conclusion: Based on the results of the study, there was no significant association between body mass index and mild, severe, and eclampsia. Further research should be conducted and developed for prevention and lifestyle intervention in preeclampsia.
References
Anto, E. O., Boadu, W. I. O., Ansah, E., Tawiah, A., Frimpong, J., Tamakloe, V. C. K. T., Korsah, E. E., Acheampong, E., Asamoah, E. A., Opoku, S., Adua, E., Afrifa-Yamoah, E., Annani-Akollor, M. E., Anto, A. O., & Obirikorang, C. (2023). Prevalence of preeclampsia and algorithm of adverse foeto-maternal risk factors among pregnant women in the Central Region of Ghana: A multicentre prospective cross-sectional study. PLOS ONE, 18(6), e0288079. https://doi.org/10.1371/journal.pone.0288079
Beckett, A. G., McFadden, M. D., & Warrington, J. P. (2023). Preeclampsia history and postpartum risk of cerebrovascular disease and cognitive impairment: Potential mechanisms. Frontiers in Physiology, 14. https://doi.org/10.3389/fphys.2023.1141002
Bilano, V. L., Ota, E., Ganchimeg, T., Mori, R., & Souza, J. P. (2014). Risk factors of pre-eclampsia/eclampsia and its adverse outcomes in low- and middle-income countries: A WHO secondary analysis. PLoS ONE. https://doi.org/10.1371/journal.pone.0091198
Burton, G. J., Redman, C. W., Roberts, J. M., & Moffett, A. (2019). Pre-eclampsia: pathophysiology and clinical implications. BMJ, 366. https://doi.org/10.1136/BMJ.L2381
Ephraim, R., Doe, P., Amoah, S., & Antoh, E. (2014). Lipid profile and high maternal body mass index is associated with preeclampsia: A case-control study of the Cape Coast Metropolis. Annals of Medical and Health Sciences Research, 4(5), 746. https://doi.org/10.4103/2141-9248.141542
Kivelä, J., Sormunen-Harju, H., Girchenko, P. V, Huvinen, E., Stach-Lempinen, B., Kajantie, E., Villa, P. M., Reynolds, R. M., Hämäläinen, E. K., Lahti-Pulkkinen, M., Murtoniemi, K. K., Laivuori, H., Eriksson, J. G., Räikkönen, K., & Koivusalo, S. B. (2021). Longitudinal Metabolic Profiling of Maternal Obesity, Gestational Diabetes, and Hypertensive Pregnancy Disorders. The Journal of Clinical Endocrinology & Metabolism, 106(11), e4372–e4388. https://doi.org/10.1210/clinem/dgab475
Lee, W.-L., Lee, F.-K., & Wang, P.-H. (2022). Pre-pregnancy body mass index and outcome of preeclampsia. Taiwanese Journal of Obstetrics and Gynecology, 61(5), 737–738. https://doi.org/10.1016/j.tjog.2022.05.010
Mohammadi, M., Maroufizadeh, S., Omani-Samani, R., Almasi-Hashiani, A., & Amini, P. (2019). The effect of prepregnancy body mass index on birth weight, preterm birth, cesarean section, and preeclampsia in pregnant women. The Journal of Maternal-Fetal & Neonatal Medicine, 32(22), 3818–3823. https://doi.org/10.1080/14767058.2018.1473366
Motedayen, M., Rafiei, M., Rezaei Tavirani, M., Sayehmiri, K., & Dousti, M. (2019). The relationship between body mass index and preeclampsia: A systematic review and meta-analysis. International Journal of Reproductive BioMedicine. https://doi.org/10.18502/ijrm.v17i7.4857
Mrema, D., Lie, R. T., Østbye, T., Mahande, M. J., & Daltveit, A. K. (2018). The association between pre pregnancy body mass index and risk of preeclampsia: a registry based study from Tanzania. BMC Pregnancy and Childbirth, 18(1), 56. https://doi.org/10.1186/s12884-018-1687-3
Nanda, A. W., & Semarawisma, A. (2021). Association between anemia and preeclampsia: a case control study in Gorontalo region, Indonesia. International Journal of Research in Medical Sciences, 10(1), 31. https://doi.org/10.18203/2320-6012.ijrms20215031
Poniedziałek-Czajkowska, E., Mierzyński, R., & Leszczyńska-Gorzelak, B. (2023). Preeclampsia and Obesity—The Preventive Role of Exercise. International Journal of Environmental Research and Public Health, 20(2), 1267. https://doi.org/10.3390/ijerph20021267
Rana, S., Lemoine, E., Granger, J., & Karumanchi, S. A. (2019). Preeclampsia. Circulation Research, 124(7), 1094–1112. https://doi.org/10.1161/CIRCRESAHA.118.313276
Robillard, P. Y., Dekker, G., Scioscia, M., Bonsante, F., Iacobelli, S., Boukerrou, M., & Hulsey, T. C. (2019). Increased BMI has a linear association with late-onset preeclampsia: A population-based study. PLoS ONE, 14(10). https://doi.org/10.1371/JOURNAL.PONE.0223888
Rodriguez-Lopez, M., Escobar, M. F., Merlo, J., & Kaufman, J. S. (2023). Reevaluating the protective effect of smoking on preeclampsia risk through the lens of bias. Journal of Human Hypertension, 37(5), 338–344. https://doi.org/10.1038/s41371-023-00827-9
Santos, S., Voerman, E., Amiano, P., Barros, H., Beilin, L., Bergström, A., Charles, M., Chatzi, L., Chevrier, C., Chrousos, G., Corpeleijn, E., Costa, O., Costet, N., Crozier, S., Devereux, G., Doyon, M., Eggesbø, M., Fantini, M., Farchi, S., … Jaddoe, V. (2019). Impact of maternal body mass index and gestational weight gain on pregnancy complications: an individual participant data meta‐analysis of European, North American, and Australian cohorts. BJOG: An International Journal of Obstetrics & Gynaecology, 1471-0528.15661. https://doi.org/10.1111/1471-0528.15661
Shao, Y., Qiu, J., Huang, H., Mao, B., Dai, W., He, X., Cui, H., Lin, X., Lv, L., Wang, D., Tang, Z., Xu, S., Zhao, N., Zhou, M., Xu, X., Qiu, W., Liu, Q., & Zhang, Y. (2017). Pre-pregnancy BMI, gestational weight gain and risk of preeclampsia: A birth cohort study in Lanzhou, China. BMC Pregnancy and Childbirth, 17(1), 1–8. https://doi.org/10.1186/S12884-017-1567-2/TABLES/3
Singgih, R., & Firmansyah, Y. (2020). Assessment of the Neutrophil Lymphocyte Ratio and Mean Platelet Volume in Pregnancy. Bioscientia Medicina : Journal of Biomedicine and Translational Research, 5(1), 85–93. https://doi.org/10.32539/bsm.v5i1.161
Singgih, R., Firmansyah, Y., & Dewi, A. K. (2021). Clinical ability of neutrophil–lymphocyte ratio in pregnancy as a predictor of preeclampsia. Journal of SAFOG, 13(3), 121–126. https://doi.org/10.5005/jp-journals-10006-1892
Soomro, S., Kumar, R., Lakhan, H., & Shaukat, F. (2019). Risk Factors for Pre-eclampsia and Eclampsia Disorders in Tertiary Care Center in Sukkur, Pakistan. Cureus. https://doi.org/10.7759/cureus.6115
Tassi, A., Sala, A., Mazzera, I., Restaino, S., Vizzielli, G., & Driul, L. (2023). Long-term outcomes of patients with preeclampsia, a review of the literature. Hypertension in Pregnancy, 42(1). https://doi.org/10.1080/10641955.2023.2217448
Venkatesh, S. S., Ferreira, T., Benonisdottir, S., Rahmioglu, N., Becker, C. M., Granne, I., Zondervan, K. T., Holmes, M. V., Lindgren, C. M., & Wittemans, L. B. L. (2022). Obesity and risk of female reproductive conditions: A Mendelian randomisation study. PLOS Medicine, 19(2), e1003679. https://doi.org/10.1371/journal.pmed.1003679
Yusrawati, Saputra, N. P. K., Lipoeto, N. I., & Machmud, R. (2017). Analyses of Nutrients and Body Mass Index as Risk Factor for Preeclampsia. The Journal of Obstetrics and Gynecology of India, 67(6), 409–413. https://doi.org/10.1007/s13224-017-0982-7
